Repetitive amiodarone administration causes liver damage via adipose tissue ER stress-dependent lipolysis, leading to hepatotoxic free fatty acid accumulation

AMD chronic administration induces hepatic lipid accumulation by several mechanisms, including induction of ER stress, impairment β-oxidation, and inhibition triacylglycerol secretion. Our study shows that repetitive treatment not only stress but also adipose tissue lipolysis free fatty acids enrichment palmitate in the total lipids. Understanding toxicity mechanisms would help devise ways to limit liver damage.